Psychedelic-Enhanced Therapy: to treat anxiety, depression, trauma, addiction and other mental health conditions. A growing body of evidence suggests that psychedelics dissolve the ego and disrupt the Default Mode Network (DMN), the part of the brain associated with mental chatter, self-absorption, memories, and emotions. Anytime you’re anxious about the future or fretting over the past, or engaged in compulsive self-reflection, this part of the brain lights up. When researchers looked at images of brains on psychedelics, they discovered that the DMN shuts down almost entirely.